Family history of a known mutation in a cancer predisposition gene

Individuals of Ashkenazi Jewish ethnicity known to be at increased risk for cancer predisposition

Cancer at a young age less than 50 years

Multiple primary cancers in a single individual

Bilateral or multifocal cancers

Same type of cancer in close relatives (same side of a family)

Rare tumors (e.g. retinoblastoma, adrenocortical carcinoma)

Unusual cancer presentation

Uncommon tumor histology

Rare cancers known to be associated with genetic syndromes

Breast, ovarian, fallopian tube, or primary peritoneal cancer

Uterine cancer

Thyroid cancer

Pancreatic cancer

Prostate cancer

Bone cancer