- Family history of a rare condition
- Cardiac disease (see cardiogenetics)
- Early onset neurologic diseases (stroke, dementia, Parkinson’s)
- Vision loss, macular degeneration, retinal disease
- Joint pain, hypermobility, frequent dislocations, fractures
- Connective tissue disorders (Ehlers-Danlos syndrome, Marfan Syndrome)
- Hereditary hemorrhagic telangiectasia
- Pulmonary diseases: idiopathic pulmonary fibrosis, arterial hypertension
- Renal diseases: Proteinuria, chronic renal failure, polycystic kidney disease
- Liver diseases: Wilson’s disease, unknown etiology liver failure
- Skin conditions, unusual rash or eczema
- Maturity-onset diabetes of the young (MODY)
- Hypoglycemia and hyperinsulinemia
